Researchers at the Washington University School of Medicine’s Department of Psychiatry recently carried out genetic linkage analyses of DSM-IV-diagnosed major depressive disorder in two samples that are part of the Nicotine Addiction Genetics project, an international consortium focused on tobacco dependence. “We used an affected sibling-pair design, in which at least two adult offspring per family reported a history of DSM-IV major depressive disorder, and tested for linkage,” said the group in its report. “Results appear to confirm a genome-wide significant linkage signal at chromosome 3p25-3p26.” The authors note that their finding, in light of previous studies, raises the possibility of common genetic influences across major depressive disorder and smoking-related behavior, or of gene-by-environment (i.e., smoking) interaction effects on major depressive disorder.
The content of Psychiatric News does not necessarily reflect the views of APA or the editors. Unless so stated, neither Psychiatric News nor APA guarantees, warrants, or endorses information or advertising on this site. Clinical information is not peer reviewed and thus should be independently verified.