Both groups showed reduction in depressive symptoms and improved function, but no significant reduction in apathy symptoms; there were no group differences between those who received memantine and those who received placebo. “Memantine was not associated with superior affective or functional outcome compared with placebo in medically rehabilitating older adults with depressive and apathy symptoms,” wrote the researchers online December 16 in the International Journal of Geriatric Psychiatry.
Memantine's benefit in the treatment of Alzheimer's disease has also been recently questioned. Read more in the Journal Digest feature of Psychiatric News.
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